South African Covid variant makes current crop of vaccines 30% less effective, SAGE warns

The South African coronavirus variant may make vaccines 30 per cent less effective, the Government’s scientific advisers have warned.

Analysis by SAGE found the strain can cause up to a 10-fold decrease in the production of antibodies in vaccinated or previously infected people.

While antibodies are not the only part of the immune response against Covid – white blood cells also help – they play a crucial role in fighting off the infection.

In its 83rd meeting on March 12, SAGE said the drop in antibodies ‘translates into a potential 30 per cent drop in vaccine efficacy’.  

Its review found the variant was able to infect patients infected with older strains in South Africa and that data suggested some immunised patients will still catch it.

But the expert group stressed it is still not clear ‘what the implications are for protection from severe disease’.

The South African strain – officially known as B.1.351 – has three key mutations on its spike protein which help it ‘hide’ from the immune system, E484K, N501Y and K417N.

Covid uses its spike to latch onto human cells and the current crop of vaccines have been designed to train people’s bodies to recognise that protein. 

SAGE said the Brazilian P.1 variant was less worrying, because it has fewer concerning mutations, but it might still be somewhat vaccine resistant.  

The emergence and rise of the South African and Brazilian strains abroad has made summer holidays this year increasingly unlikely.

Ministers and their scientific advisers are keen not to allow a huge dump of imported cases of the mutant strains which could undermine the country’s vaccine rollout.

The South African coronavirus variant may make vaccines 30 per cent less effective, the Government's scientific advisers have said said (file)

The South African coronavirus variant may make vaccines 30 per cent less effective, the Government’s scientific advisers have said said (file) 

They variants which have been spotted in the UK: Public Health England's latest find was a strain believed to have spawned in New York

They variants which have been spotted in the UK: Public Health England’s latest find was a strain believed to have spawned in New York 

The analysis looked at studies in South Africa which found people infected with older strains of Covid were just as likely to catch the new variant as patients who’d never had any infection.

It said this was evidence ‘prior infection, with 2020 prototype SARS-CoV-2, did not reduce the risk of subsequent Covid-19 illness likely due to the B.1.351 variant’.

India claims it has spotted a ‘double mutant’ Covid variant that spreads easier and may escape vaccines. 

India has claimed it has spotted a ‘double mutant’ Covid variant that may spread easier and make vaccines less potent. 

Government-backed researchers detected the strain in samples taken in the western state of Maharashtra. 

They suggested the variant is a hybrid of two different Covid strains — a rare event which occurs when two viruses merge together inside an infected person. 

Indian health officials said the variant’s mutations signal a risk of ‘immune escape and increased infectivity’. But they added that the variant had not been detected in high enough numbers to be behind India’s latest wave of infections.

The variant, yet to be named, has two main mutations that concern experts. E484Q and L452R — both found on the spike protein, which the immune system targets to fight off the coronavirus — are thought to play a role in transmissibility and antibody escape.

However, British scientists told MailOnline today there was ‘no evidence’ to suggest the virus is a ‘recombination variant’, when two strains merge.

Dr Simon Clarke, a molecular biologist at Reading University, said it was more likely to be another variant that randomly spawned with those two mutations.

He added: ‘We should not try to make this out to be something it’s not because it is most likely the same thing we’ve seen in other variants, like the one in Brazil and South Africa — which all have multiple mutations on their spike protein. I’ve not yet seen any evidence to suggest it is a recombinant.’ 

Only one hybrid version of coronavirus has been spotted so far. It was found in the US and was a mix between the Kent variant and a strain found in California.

Real-world data of the strain’s impact on current vaccines was scarce, SAGE said, with only one randomised clinical trial by AstraZeneca directly measuring its effect.

That small study, of adults under 65, showed the vaccine was just 10 per cent effective at stopping severe disease. 

Johnson and Johnson’s vaccine was found to be about 64 per cent effective in South Africa – though it did not break down specific variants – while a jab made by the American firm Novavax was 60 per cent effective in the country, but again did not look specifically at different types of virus.

SAGE said: ‘Overall, this suggests a modest decrease in vaccine efficacy against B.1.351 infection. 

‘From analysis of clinical trial results and laboratory studies, a provisional conclusion is that as the neutralising antibody (NAb) titres fall against variants, we can expect a decrease in vaccine efficacy.’

Meanwhile, the analysis found reinfection from the Kent variant was ‘rare’ and that ‘antibodies to earlier viruses will continue to provide protection’, as well as the vaccines.

The South African version is thought to be at least 60 per cent more infectious than regular Covid, but it does not appear to have an ‘evolutionary edge’ over the Kent strain, which is why experts believe there has not been a huge outbreak in the UK.

Public Health England has so far spotted 412 cases of the South African strain in the UK, although it is likely to be more widespread because officials only analyse a handful of positive samples.

It comes as all lorry drivers entering England face compulsory Covid-19 tests to fight the threat of new  variants – despite fears the scheme could disrupt food supplies.

Hauliers, border force officials and other workers have been exempt from testing when entering the UK, but Whitehall is set to announce a change this weekend.

Those arriving will have to take a customised test once they are in Britain, rather than at the borders, to avoid  delays that could lead to empty shelves in supermarkets and shops.

Despite concerns over delays, Boris Johnson said on Wednesday that the Government ‘can’t rule out tougher measures’.

A Government source told The Telegraph: ‘The potential impact is hard to quantify but there is a concern that an inbound testing regime will introduce an additional burden that could cause significant points of friction.’ 

Those staying longer than two days will have to have a test within 48 hours of arriving and then every 72 hours, with fines similar to the £2,000 penalties for travellers who fail to test during home quarantine. 

Border Force staff engaged in cross Channel work and similar arrangements for those working on trains and ferries in the area will have to take three mandatory tests a week.

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